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Flucloxacillin – getting the right antibiotic to the right patient, at the right time

Responsible prescription of antibiotics results in better patient outcomes and reduced antibiotic resistance.



According to the World Health Organisation, rational use of medicines requires that ‘patients receive medications appropriate to their clinical needs, in doses that meet their own individual requirements, for an adequate period of time, and at the lowest cost to them and their community.’ 1

Irrational prescribing is a manifestation of inappropriate medicine use that occurs when medicines are not prescribed in accordance with guidelines based on scientific evidence to ensure safe, effective and economic use.2 Along with the development of antimicrobial-resistant organisms, excessive and inappropriate use of antimicrobials cause other serious adverse effects, such as increased morbidity and mortality, drug toxicity, longer hospitalisation times and higher costs.2

The South African Antibiotic Stewardship Programme (SAASP) is provided as an information resource for all healthcare workers to assist in the appropriate prescribing of antimicrobials. Relevant information from South African and international guidelines, textbooks, key publications and expert opinion is summarised for clinicians in this resource.3

The rational use of Flucloxacillin:

Pharmacological properties and therapeutic indications 4

Flucloxacillin is a beta-lactam antibiotic of the penicillin class, indicated for the treatment of different types of infections caused by susceptible Gram-positive organisms, including beta-lactamase-producing staphylococci and streptococci.


  • susceptible Gram-positive organisms, including beta-lactamase producing staphylococci and streptococci (excluding Enterococcus and methicillin-resistant Staphylococci).
  • The STGs and EML for South Africa, published by the National Department of Health, provide guidance on the rational and appropriate use of Flucloxacillin based on individual indications. Their guidance is summarised in Table 1 below

For more information with regards to the contraindications4, cautions4, adverse reactions4, monitoring4 and mechanism of action4 please view the product listing for Medreich Flucloxacillin in the app.

Flucloxacillin generics are available in South Africa

Flucloxacillin availability in South Africa:4

  • Flucloxacillin, as a single agent, is available as an oral preparation in a 250mg capsule.
  • Flucloxacillin, as a combination agent with Ampicillin, is available as an oral preparation in a 250mg/250mg capsule or 125mg/125mg suspension.

For list of references, CLICK HERE

For Current and future Oethmaan Biosims brands, please refer to the product tab.

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